Researchers at the
Massachusetts Institute of Technology (MIT) and Georgia Tech have automated the process of finding and recording information from cells in living brains, as reported in the May 6 issue of
Nature Methods.
Graphic courtesy of the Boyden Lab
"Autopatching makes recording the electrical and circuit properties [of cells] straightforward and effortless for the operator," Craig Forest, assistant professor at Georgia Tech and one of the members of the research team, told TechNewsWorld.
This technology "can be integrated with molecular analysis, such as gene expression measurement, and cell staining for shape, or morphology, measurement. Together, electrophysiology, gene expression and morphology comprise a complete description for healthy cells and cells that are under the influence of drugs or diseased for comparison," he said.
"For example, such a study could be used to discover the cellular processes underlying diseases like epilepsy, narcolepsy, Alzheimer's ... or for drugs like anesthesia," he added.